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A Research Institute

As a renowned African research institute in a world class African University, Wits RHI addresses some of the greatest public health concerns affecting our region, including HIV and its related problems, sexual and reproductive health and vaccinology.

Wits RHI is the largest research institute affiliated with the Faculty of Health Sciences at the University of the Witwatersrand.

The institute was established by Prof Helen Rees in 1994 to assist the new South African government to formulate and implement new national policies around sexual and reproductive health. It has shaped itself as an African institute leading multidisciplinary research, focusing mainly on HIV, sexual reproductive health (SRH), and vaccine-preventable diseases (VPDs). Recently, Wits RHI expanded its portfolio to include COVID-19 and other respiratory pathogens, emerging global health crises (including antimicrobial resistance), and climate change and health.

Its research studies are carried out in collaboration with multiple partners within and outside the African region. 

Wits RHI in Numbers

Staff Members
3000+
Research and Implementation Sites
50
Current Active Grants
93
Academic Joint Appointments
51
Provides technological support to national, regional, and global committees (2022)
162
Published academic journals and book chapters (2023)
111

Latest Projects And News

Projects

CHOMA

Combining HIV Prevention Options With Mental Health Service Delivery For Adolescent Girls (CHOMA). Youth Friendship Bench SA Optimization of the Friendship Bench mental health intervention for adolescent girls and young women in South African PrEP delivery settings -Youth Friendship Bench SA. Rationale The study aims to evaluate two primary outcomes among young South African women after a 3-month period: Comparing the proportion of young South African women who exhibit good adherence to PrEP (determined by tenofovir levels detected in a point-of-care urine assay) between those receiving the Youth Friendship Bench SA in addition to standard-of-care mental health services and those receiving standard-of-care mental health services alone. Comparing the proportion of young South African women with decreased symptoms of common mental disorders (assessed via SRQ-20 scores) between those receiving the Youth Friendship Bench SA along with standard-of-care mental health services and those receiving standard-of-care services alone. The primary outcome for PrEP…

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Projects

CHOMA

Combining HIV Prevention Options With Mental Health Service Delivery For Adolescent Girls (CHOMA). Youth Friendship Bench SA Optimization of the Friendship Bench mental health intervention for adolescent girls and young…

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Projects

PrEP SMART

Evaluation of stepped PrEP adherence support for young South African women using a SMART design. Rationale To evaluate the proportion of young South African women who adhere well to PrEP…

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Projects

Pausing Antiretroviral Treatment Under Structured Evaluation (PAUSE)

A Phase I, Randomized, Placebo-Controlled Trial to Evaluate the Safety, Antiviral, and Immunomodulatory Effects of Combining Broadly Neutralizing Antibodies 3BNC117-LS-J and 10-1074-LS-J in ART-Treated Adults with HIV in sub-Saharan Africa,…

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Projects

IMPAACT 2028

Long-Term Clinical, Immunologic, and Virologic Profiles of Children who Received Early Treatment for HIV. Rationale Early treatment of infants living with HIV offers a unique population in which to investigate…

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Latest News From Around The World Of Wits RHI

Brink N, Lakhoo DP, Solarin I, Maimela G, von Dadelszen P, Norris S, Matthew F. Chersich MF, Climate and Heat-Health Study Group. (2024)

Our Researchers

Our Donors and Partners

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