Top

A Research Institute

As a renowned African research institute in a world class African University, Wits RHI addresses some of the greatest public health concerns affecting our region, including HIV and its related problems, sexual and reproductive health and vaccinology.

Wits RHI is the largest research institute affiliated with the Faculty of Health Sciences at the University of the Witwatersrand.

The institute was established by Prof Helen Rees in 1994 to assist the new South African government to formulate and implement new national policies around sexual and reproductive health. It has shaped itself as an African institute leading multidisciplinary research, focusing mainly on HIV, sexual reproductive health (SRH), and vaccine-preventable diseases (VPDs). Recently, Wits RHI expanded its portfolio to include COVID-19 and other respiratory pathogens, emerging global health crises (including antimicrobial resistance), and climate change and health.

Its research studies are carried out in collaboration with multiple partners within and outside the African region. 

Wits RHI in Numbers

Staff Members
3000+
Research and Implementation Sites
50
Current Active Grants
93
Academic Joint Appointments
51
Provides technological support to national, regional, and global committees (2022)
162
Published academic journals and book chapters (2023)
111

Latest Projects And News

Projects

PrEP SMART

Evaluation of stepped PrEP adherence support for young South African women using a SMART design. Rationale To evaluate the proportion of young South African women who adhere well to PrEP with regular clinic visits and mHealth interventions alone, the proportion of women who adhere well to PrEP with intensified interventions (i.e. monthly visits and special issue counselling or quarterly visits with drug-level feedback about recent adherence), and the optimal sequence of intensifying adherence support among young women who have low adherence after the first two months of use. Investigators Sinead Delany-Moretlwe, Protocol Co-Chair Latest Update April 2024 For more about PrEP SMART please email rhicomms@wrhi.ac.za

View project

Projects

PrEP SMART

Evaluation of stepped PrEP adherence support for young South African women using a SMART design. Rationale To evaluate the proportion of young South African women who adhere well to PrEP…

View project

Projects

Pausing Antiretroviral Treatment Under Structured Evaluation (PAUSE)

A Phase I, Randomized, Placebo-Controlled Trial to Evaluate the Safety, Antiviral, and Immunomodulatory Effects of Combining Broadly Neutralizing Antibodies 3BNC117-LS-J and 10-1074-LS-J in ART-Treated Adults with HIV in sub-Saharan Africa,…

View project

Projects

IMPAACT 2028

Long-Term Clinical, Immunologic, and Virologic Profiles of Children who Received Early Treatment for HIV. Rationale Early treatment of infants living with HIV offers a unique population in which to investigate…

View project

Projects

MATRIX-002

Trial to Assess Acceptability and Safety of Two Placebo Prototype Vaginal Films Rationale Topical microbicides play a crucial role in mitigating the risk of HIV transmission through sexual contact by…

View project

Latest News From Around The World Of Wits RHI

Brink N, Lakhoo DP, Solarin I, Maimela G, von Dadelszen P, Norris S, Matthew F. Chersich MF, Climate and Heat-Health Study Group. (2024)

Our Researchers

Our Donors and Partners

Stay up to date

Get updates on news, resources, events and happenings from Wits RHI.