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MATRIX-002

MATRIX-002

ARISE

MTN 042

MTN-042 is a Phase 3B, randomized, open-label safety and pharmacokinetic trial focusing on the use of the Dapivirine Vaginal Ring (VR) and Oral FTC/TDF during…

Pfizer RSV Vaccine Study In HIV-Infected Pregnant Woman

A Phase 3 trial has been initiated as a randomized, double-blinded, placebo-controlled study to assess the safety, tolerability, and immunogenicity of the Respiratory Syncytial Virus…

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MATRIX-002

Trial to Assess Acceptability and Safety of Two Placebo Prototype Vaginal Films Rationale Topical microbicides play a crucial role in mitigating the risk of HIV transmission through sexual contact by applying them to the genital or rectal mucosa. Among various delivery options, vaginal films stand out as a compelling choice…

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ARISE

Acceptability Research on Integrated Point of Care Sexually Transmitted Infection (STI) Testing and Expedited Partner Therapy (EPT). Rationale Rates of curable sexually transmitted infections (STIs) are escalating globally, particularly in South Africa, where they rank among the highest worldwide. Concurrently, South Africa faces the highest HIV-1 incidence globally, notably among…

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MTN 042

MTN-042 is a Phase 3B, randomized, open-label safety and pharmacokinetic trial focusing on the use of the Dapivirine Vaginal Ring (VR) and Oral FTC/TDF during pregnancy. Rationale This multicenter, prospective study aims to assess the safety, adherence, and acceptability of the DPV VR (25 mg) inserted every 4 weeks, along…

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Pfizer RSV Vaccine Study In HIV-Infected Pregnant Woman

A Phase 3 trial has been initiated as a randomized, double-blinded, placebo-controlled study to assess the safety, tolerability, and immunogenicity of the Respiratory Syncytial Virus (RSV) Prefusion F Subunit Vaccine in pregnant participants living with HIV and their infants. Maternal immunization stands as a promising strategy for preventing infant diseases.…

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The HEat and HEalth African Transdisciplinary (HEAT) Center

The HEat and HEalth African Transdisciplinary (HE2AT) Center is a five-year project funded by the National Institutes of Health, Common Research Fund. It was launched in 2022 and consists of a data science and analytics platform that helps understand how extreme heat affects vulnerable groups in Africa. The consortium includes…

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Wits RHI PEPFAR COVID-19 Response

Wits RHI PEPFAR funded programmes (Tshwane CDC, Lejweleputswa APACE and Key Populations - USAID) in collaboration with PASP-ELMA, Project PrEP-UNITAID, and School-Based Programme - USAID) have established a PEPFAR RHI COVID-19 Response Committee which serves as a nerve centre to coordinate an internal Wits RHI COVID-19 response and to leverage…

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Dual Prevention Pill (DPP) for HIV and Pregnancy Prevention

A qualitative formative research study among women and health care providers in Johannesburg, South Africa. The DPP formative study will use focus group discussions and in-depth interviews to understand women’s interest in using a DPP for HIV and pregnancy prevention and gather inputs regarding informational materials needed for DPP introduction,…

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Accelerating Program Achievements to Control the Epidemic (APACE)

Primary Objective Wits RHI and USAID entered a partnership that will result in accelerated efforts to control the HIV epidemic in South Africa. Wits RHI will work closely with the Department of Health and other key stakeholders to manage the “Accelerating Program Achievements to Control the Epidemic (APACE)” in the…

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APACE – Accelerating Program Achievements to Control the Epidemic

Wits RHI PEPFAR funded programmes (Tshwane CDC, Lejweleputswa APACE and Key Populations - USAID) in collaboration with PASP-ELMA, Project PrEP-UNITAID, and School-Based Programme - USAID) have established a PEPFAR RHI COVID-19 Response Committee which serves as a nerve centre to coordinate an internal Wits RHI COVID-19 response and to leverage…

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ENBEL

ENhancing BELmont Research Action to support EU policy making on climate change and health (The ENBEL project) ENBEL aims to bring together leading researchers and policy groups in the EU and Africa who are working on climate change and health. The consortium intends to support EU climate change and health…

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CHARISMA

Gender-based violence is widespread—as many as 1 in 3 women worldwide are subjected to some or multiple forms. Research to date suggests that male partner approval or active support is often desired, required, or culturally indicated for women’s microbicide use, although use is female initiated and designed to empower women…

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Many infectious diseases have emerged; others have unexpectedly reappeared. The link between environmental sustainability and health is generally misunderstood policy-makers. We acknowledge that social cohesion and sustainability is a necessary basis for health.

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