Wits RHI
Current projects
Current projects
HPTN 108/ PAUSE STUDY
The HPTN 108 Study, also known as the PAUSE Study, is a Phase 1, randomized, placebo-controlled trial investigating the safety, efficacy and tolerability of the combination of two long-acting broadly neutralizing antibodies (bNAbs), 3BNC117-LS-J and 10-1074-LS-J, in ART-treated adults living with HIV in sub-Saharan Africa. The study focuses on whether these bNAbs, administered through intravenous infusion, will be safe, well-tolerated, and capable of maintaining durable viral suppression in the absence of antiretroviral therapy (ART) during a monitored analytical treatment interruption (ATI).
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Operation Gophelega
Operation Gophelega kicked off in January 2022 and is one of the largest grants Wits RHI has ever received from the US President’s Emergency Plan for AIDS Relief and the US Centers for Disease Control and Prevention. Gophelega is at the heart of Wits RHI’s district support partnership programme and our largest health system strengthening initiative to date. The team are working alongside district health services in Tshwane and Ekurhuleni to improve and innovate the delivery of HIV and TB services.
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MOSAIC
Maximizing OptionS to Advance Informed Choice for HIV Prevention (MOSAIC). MOSAIC works across multiple countries to implement user-centered research and research translation efforts to identify, understand, and remove barriers to new product introduction, access, and use; coordinate and provide technical assistance to global, national, and subnational stakeholders to expedite product launch and scale-up; and strengthen the capacity of a wide range of local partners to perform essential functions that support the introduction of HIV prevention products.
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The HEat and HEalth African Transdisciplinary (HEAT) Center
The HEat and HEalth African Transdisciplinary (HE2AT) Center is a five-year project funded by the National Institutes of Health, Common Research Fund. It was launched in 2022 and consists of a data science and analytics platform that helps understand how extreme heat affects vulnerable groups in Africa.
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PALESA
A Pilot Randomized Controlled Trial to Assess a Model of Decentralised STI-Self Testing and Risk Self-Assessment Among Adolescent Girls and Young Women in South Africa to Trigger PrEP Re-start (PALESA). In South Africa (SA), adolescent girls and young women (AGYW) experience high rates of incident HIV infection. HIV pre-exposure prophylaxis (PrEP) has the potential to impact HIV incidence when used with consistent adherence to the required dosing schedule.
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HIGH Horizons (Heat Indicators for Global Health) Study
HIGH Horizons: Heat Indicators for Global Health. Monitoring, Early Warning Systems and health facility interventions for pregnant and postpartum women, infants and young children and health workers. Rationale The HIGH Horizons Study is designed to address critical knowledge gaps regarding the direct and indirect effects of heat exposure on maternal,…
Heat Adaptation for Pregnant women and Infants (HAPI) study
Heat Adaptation for Pregnant women and Infants (HAPI) study Summary of the study Temperatures in Southern Africa are rising at twice the global rate, with major health implications for maternal and newborn health. In these conditions, the options for adaptation are limited, and single-component interventions are likely to be poorly…
South African Population Research Infrastructure Network (SAPRIN)
South African Population Research Infrastructure Network (SAPRIN): A National Research Infrastructure of Health and Demographic Surveillance System (HDSS) Nodes. Rationale Research in the human and social sciences plays a crucial role in driving social, economic, and cultural development and transformation in South Africa. The overarching goal is to enhance the…
CHAMNHA (Climate, Heat, and Maternal and Neonatal Health in Africa)
Investigating the impact of environmental heat exposure around the time of childbirth on women's and children's health a community and facility-based qualitative inquiry in Burkina Faso and Kenya. Rationale The frequency and intensity of heat waves have increased in sub-Saharan Africa (SSA) and are set to escalate in the coming…
South African Population Research Infrastructure Network (SAPRIN)
South African Population Research Infrastructure Network (SAPRIN): A GRT-INSPIRED Sub Study of COVID-19 Perceptions, Impacts and Seroprevalence Among Residents of Atteridgeville, Melusi and Hillbrow in Gauteng, South Africa Rationale The global COVID-19 pandemic is an exceptional emergency, and presents a serious risk to human health and livelihoods, especially in countries…
The HEat and HEalth African Transdisciplinary (HEAT) Center
The HEat and HEalth African Transdisciplinary (HE2AT) Center is a five-year project funded by the National Institutes of Health, Common Research Fund. It was launched in 2022 and consists of a data science and analytics platform that helps understand how extreme heat affects vulnerable groups in Africa. The consortium includes…
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Established in 1994, Wits RHI is part of the Faculty of Health Sciences and the largest research institute of the University of the Witwatersrand.