Wits RHI
Current projects
Current projects
HPTN 108/ PAUSE STUDY
A Phase I, Randomized, Placebo-Controlled Study of the Safety, Antiviral & Immunomodulatory Activity of Broadly Neutralizing Antibodies 3BNC117-LS-J and 10-1074-LS-J in Combination in ART-treated Adults in sub-Saharan Africa Living with HIV during a Monitored Analytical Treatment Interruption.
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HOPE II Study
Efficacy of single-dose nonavalent Human Papillomavirus (HPV) Vaccination boost to prevent incident persistent HPV 16/18/31/33/45/52/58 infection among women living with HIV who were previously vaccinated against HPV 16/18.
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WONDERS 2 Study
Phase 2/3 randomized, multicenter, active-controlled study to evaluate the safety and efficacy of an oral weekly regimen of GS-1720 in combination with GS-4182 versus BVY in treatment-naive PWH.
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SHIELD Study
This study, evaluating Fostemsavir for HIV-1-infected children and adolescents with multidrug-resistant HIV, is actively recruiting from the CMJAH Paediatric HIV Clinic, with two participants enrolled so far. Recruitment is ongoing and expected to conclude by Q3 2025.
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IMPAACT 2036 CRAYON Study
(Cabotegravir and Rilpivirine Long-Acting Injections in YOung ChildreN) is a Phase I/II clinical trial focused on evaluating the safety, tolerability, acceptability, and pharmacokinetics of a dual long-acting injectable antiretroviral regimen for children living with HIV-1. This study involves oral and injectable formulations of cabotegravir (CAB) and rilpivirine (RPV) in virologically suppressed children aged 2 to under 12 years, weighing between 10 kg and 40 kg.
View projectSexual and Reproductive Health
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HOPE II Study
Human Papillomavirus One-Dose-vaccine Prevention Efficacy among Women Living with HIV (HOPE II) Study Study Rationale The HOPE II Study aims to explore whether a single-dose HPV vaccine can effectively prevent persistent HPV infections in women living with HIV, particularly targeting HPV strains linked to cervical cancer. This study focuses on…
BIYELA STUDY
BIYELA: Bexsero Immunisation in Young Women in Africa. The BIYELA Study is a Phase 3 randomized, double-blinded, placebo-controlled trial evaluating the efficacy of the meningococcal serogroup B vaccine rMenB+OMV NZ (Bexsero) in preventing gonococcal infection among individuals born female in South Africa. This study focuses on sexually transmitted infection (STI)…
Technical Support National Department of Health for HIV Prevention & Pre-Exposure Prophylaxis
Rationale Whilst the Department of Health has made significant gains in the introduction and the scale- of oral pre-exposure prophylaxis as an HIV prevention intervention, at 78% of public PHC facilities support is required to achieve of PHC 100% coverage. In the following 2 years, the department will focus strengthening…
EPIC
Evaluation of Pharmacokinetic drug-drug Interactions between hormonal Contraceptives and doravirine-containing ART among women living with HIV in South Africa (EPIC). Rationale While DOR-containing antiretroviral therapy (ART) has been studied in two large clinical trials, the representation of women, especially African women, has been disproportionately low at only 16-17% and 6-10%,…
Project PrEP
Project PrEP: Integrating PrEP into Comprehensive Services for Adolescent Girls and Young Women Rationale Project PrEP is a Unitaid-funded initiative that began in 2018, aimed at integrating oral PrEP into comprehensive sexual and reproductive health (SRH) services for adolescent girls and young women (AGYW). The project operates across eight fixed…
ABBOTT
Sample Collection for the Development and Evaluation of Rapid Tests for Chlamydia trachomatis and Neisseria gonorrhoeae – outside of US (OUS). Rationale Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections are significant contributors to avoidable infertility. Many cases of CT and NG go undiagnosed and unreported, leading to frequent reinfection…
Integrating PrEP into Comprehensive Services for Adolescent Girls and Young Women
AGYW in South Africa (aged between 15 and 24 years) have the highest HIV incidence, with young women in their early 20s having a four-fold burden compared to their male peers: approximately 1,745 new HIV infections occur in this cohort every week, and one third of teenage girls become pregnant…
PALESA
A Pilot Randomized Controlled Trial to Assess a Model of Decentralised STI-Self Testing and Risk Self-Assessment Among Adolescent Girls and Young Women in South Africa to Trigger PrEP Re-start (PALESA). Rationale In South Africa (SA), adolescent girls and young women (AGYW) face significant rates of new HIV infections. HIV pre-exposure…
ARISE Study
ARISE: Acceptability Research on Integrated Point of Care Sexually Transmitted Infection (STI) Testing and Expedited Partner Therapy (EPT) Rationale Rates of curable sexually transmitted infections (STIs) are rising globally, with South Africa experiencing some of the highest STI rates. Additionally, South Africa has the highest HIV-1 incidence, particularly among young…
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Established in 1994, Wits RHI is part of the Faculty of Health Sciences and the largest research institute of the University of the Witwatersrand.