South Africa CATALYST Study


MOSAIC South Africa is excited to announce the official launch of the CATALYST (Catalyzing Access to New Prevention Products to Stop HIV) Study after months of preparation and anticipation. The launch was held at the Wits RHI Key Populations clinic in Johannesburg on 11 August 2023 and was attended by clients seeking services, representatives from the civil society organization, Sisonke, Department of Health, and the USAID South Africa Mission. Speaking during the launch, Dr Letitia Robinson, Acting USAID Bilateral Health Office Director, emphasized the importance of having real-world actionable data to maximize the impact that new PrEP products may have on reducing new HIV infections. Participants were engaged through interactive activities including the ‘Drive with Sasha’ and a game called ‘pop it’ that allowed participants to showcase their HIV prevention knowledge prowess. The first two study participants were enrolled whilst the launch event was underway. The team looks forward to enrolling more participants in the coming weeks.

CATALYST is implemented through the MOSAIC (Maximizing Options to Advance Informed Choice for HIV Prevention) project, a five-year global project funded by the U.S. President’s Plan for AIDS Relief (PEPFAR) through the U.S. Agency for International Development (USAID). As part of CATALYST, women in six PEPFAR sites in Johannesburg and Lejweleputswa will have the choice of taking oral PrEP, the PrEP ring, and later CAB PrEP (once it has been approved for use in South Africa). The study is designed to generate evidence to accelerate access to a choice-based HIV prevention package that supports PrEP choice; addresses needs at the individual, provider, facility, and community levels; and uses quality improvement methods to refine the components of the services provided.


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