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Wits RHI

Exciting Milestone: CoVPN 3008 (Ubuntu) TB Substudy Site Activation at Wits RHI

Wits RHI is excited to announce the activation of the CoVPN 3008 (Ubuntu) TB Substudy, an observational effort that builds upon the foundational CoVPN 3008 (Ubuntu) cohort. This substudy targets the urgent need to understand tuberculosis (TB) in people living with HIV (PLWH), focusing on detecting undiagnosed cases, exploring TB biomarkers, and following the progression of confirmed TB cases.

The CoVPN 3008 (Ubuntu) cohort has provided over a year of comprehensive data on PLWH, creating a valuable foundation for this substudy. Through this new research, we aim to:

  • Identify undiagnosed TB cases, including those that are subclinical and may otherwise go unnoticed.
  • Examine participant demographics and other factors that may be linked to higher TB risk.
  • Investigate blood biomarkers that may serve as early indicators of TB, helping to detect subclinical and active infections earlier.
  • Monitor confirmed TB cases over six months to assess microbiological status and treatment responses.

This substudy will begin with a cross-sectional phase to capture undiagnosed TB in the cohort, followed by a case-cohort study to delve into potential blood biomarkers associated with the disease. Researchers will revisit confirmed TB cases after six months to track outcomes and microbiological status, allowing for a deeper understanding of TB’s progression and treatment impact in this population.

The CoVPN 3008 (Ubuntu) TB Substudy represents a critical advancement in TB research among PLWH, with the potential to improve early diagnosis, personalize treatment approaches, and ultimately enhance health outcomes. Wits RHI is proud to lead this innovative work and looks forward to sharing insights that may reshape TB detection and care for vulnerable populations globally.