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What We Do

Wits RHI is a research and implementation Institute that is dynamic, progressive, and responsive to global and local health emergencies. We pioneer cutting-edge science and innovation in the fields of infectious and vaccine preventable diseases; maternal and family health; antimicrobial resistance, climate change and emerging crises.

Our strength lies in our multi-disciplinary and holistic approach to improving health outcomes at a local and global level through research, technical assistance, advocacy, policy development, implementation science and health systems strengthening. We identify health problems through sound epidemiological methods and qualitative research, and use a range of analytic and research methods to generate evidence and test and evaluate interventions in a real word setting.

We are a part of the Faculty of Health Sciences at the University of the Witwatersrand, a world class African University, and its largest Institute.

We are a Joint United Nations Programme on AIDS (UNAIDS) and South African Medical Research Council (SAMRC) collaborating centre and a strategic partner to the United Nations Population Fund (UNFPA).

Who We Serve

Our work is focused on populations that are most in need, marginalised, or hard to reach. These include:

  • Pregnant women and mother-infant pairs
  • Women and Men
  • Adults and children living with HIV and TB

Wits RHI in Numbers

Staff Members
2500+
Research and Implementation Sites
52
Current Active Grants
67
Published Academic Journals (2024)
102

Leadership

Latest Publications

Characterizing HIV seroconversions among a cohort of oral PrEP users in South Africa

Authors

Martin CE, Ramatsoma H, Chidumwa G, Cox LA, Mullick S. (2025)

Abstract

There has been significant progress in the rollout of oral pre-exposure prophylaxis (PrEP) for the prevention of HIV. The introduction of long-acting prevention methods holds the potential to improve HIV prevention uptake and use, however, presents unique complexities regarding HIV diagnosis and potential for resistance. Quantifying and understanding the scenarios within which seroconversions occur may help to inform approaches to identifying acute HIV in programmes delivering PrEP at scale.

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Characterizing HIV seroconversions among a cohort of oral PrEP users in South Africa

Martin CE, Ramatsoma H, Chidumwa G, Cox LA, Mullick S. (2025)

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Preferences for HIV pre-exposure prophylaxis formulations and delivery among young African women: results of a discrete choice experiment

Dlamini WW, Mirembe BG, Krows ML, Peacock S, Kotze PL, Selepe P, Smit J, Mandona N, Louw C, Nuwagaba-Biribonwoha H, Omollo VO, Zwane Z, Panchia R, Mwelase N, Senne M,…

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Characteristics of children and adolescents with multidrug-resistant and rifampicin-resistant tuberculosis and their association with treatment outcomes: a systematic review and individual participant data meta-analysis

Garcia-Prats AJ, Garcia-Cremades M, Cox V, Kredo T, Dunbar R, Schaaf HS, Seddon JA, Furin J, Achar J, Radke K, Sachs T, Abubakirov A, Ahmed S, Akkerman OW, Al Ani…

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Safety and immunogenicity of Ad26.COV2.S in adolescents: Phase 2 randomized clinical trial

Tica J, Rezelj VV, Benoit Baron, van Paassen V, Zaidman J, Fairlie L, Gert Scheper, Gars ML, Struyf F, Douoguih M, Ruiz-Guiñazú J, COV3006 study group. (2025)

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Wits RHI in the News

Professor Helen Rees, Executive Director of Wits RHI, appeared on…

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Professor Sinead Delany-Moretlwe, Director of Research at Wits RHI, alongside key…

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Wits-Alive invites applications for the African Advanced Vaccinology (Afro-ADVAC) Course…

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