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What We Do

Wits RHI is a research and implementation Institute that is dynamic, progressive, and responsive to global and local health emergencies. We pioneer cutting-edge science and innovation in the fields of infectious and vaccine preventable diseases; maternal and family health; antimicrobial resistance, climate change and emerging crises.

Our strength lies in our multi-disciplinary and holistic approach to improving health outcomes at a local and global level through research, technical assistance, advocacy, policy development, implementation science and health systems strengthening. We identify health problems through sound epidemiological methods and qualitative research, and use a range of analytic and research methods to generate evidence and test and evaluate interventions in a real word setting.

We are a part of the Faculty of Health Sciences at the University of the Witwatersrand, a world-class African University.

We are a Joint United Nations Programme on AIDS (UNAIDS) and South African Medical Research Council (SAMRC) collaborating centre and a strategic partner to the United Nations Population Fund (UNFPA).

Who We Serve

Our work is focused on populations that are most in need, marginalised, or hard to reach. These include:

  • Pregnant women and mother-infant pairs
  • Women and Men
  • Adults and children living with HIV and TB

Wits RHI in Numbers

Staff Members
2000+
Research Appointments in 2024
59
Grants (2024)
75
Published Academic Journals (2024)
102

Leadership

Latest Publications

Pharmacokinetic and clinical associations between doravirine-containing ART and injectable and implantable hormonal contraceptive methods among women living with HIV in South Africa

Authors

Patel RC, Ndlovu N, Maheria P, Kgoa R, Kew L, Kapa L, Reddy K, Govindasami M, Matswake N, Sigcu N, Seedat M, Shale L, Yongo N, Hassan SA, Williams TL, Erikson DW, Scarsi KK, Palanee-Phillips T. (2025)

Abstract

Drug resistance and intolerance of dolutegravir-containing antiretroviral therapy (ART) are rising in low- and middle-income countries, resulting in a potentially increased use of doravirine-containing ART use. There are knowledge gaps regarding doravirine and hormonal contraceptive drug-drug interactions among women living with HIV (WLWH).

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Pharmacokinetic and clinical associations between doravirine-containing ART and injectable and implantable hormonal contraceptive methods among women living with HIV in South Africa

Patel RC, Ndlovu N, Maheria P, Kgoa R, Kew L, Kapa L, Reddy K, Govindasami M, Matswake N, Sigcu N, Seedat M, Shale L, Yongo N, Hassan SA, Williams TL,…

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Southern African HIV Clinicians Society guideline on pre-exposure prophylaxis to prevent HIV

Macdonald P, Nair G, Wattrus C, Mullick S, Pleaner M, Rousseau E, Subedar H, Joseph-Davey D, Hugo J, Delany-Moretlwe S, Bekker L. (2025)

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Beyond behavioural change: prioritising structural solutions to control bacterial sexually transmitted infections

Ong JJ, Unemo M, Molina J, Miranda AE, Seib KL, de Mello MB, Doherty M, Johnson CC, Delany-Moretlwe S, Fairley C. (2025)

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Community PrEP delivery for adolescent girls and young women: insights from the DREAMS PrEP Choice Study in Johannesburg, South Africa

Naidoo NP, Mthimkulu N, Jama N, Chidumwa G, Chabalala B, Mhakakora T, Parmley L, Mullick S. (2025)

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Wits RHI in the News

Prof Lee Fairlie leads South Africa’s contribution to the M72/AS01E…

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New Global Role for Prof Helen Rees at the International…

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Fake and sub-standard drugs are rife globally, but in Africa,…

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