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HOPE (HPV One and two dose Population Effectiveness) Study

Impact of 2-dose and 1-dose human papillomavirus (HPV) vaccination schedules on community level HPV prevalence in South African adolescent girls. To monitor the effectiveness of a 2-dose and 1-dose HPV vaccination schedules on community level HPV prevalence among South African adolescent girls.

Primary Outcomes

In South African adolescent girls aged 17–18 years;

  • To measure the population effectiveness of the national 2-dose vaccine schedule, delivered at age 9 years, in protecting against infection with sexually transmitted HPV16 and 18;
  • To measure the population effectiveness of a 1-dose vaccine schedule, delivered via a demonstration project to girls in Grade 10 of public school, in protecting against infection with sexually transmitted HPV16 and 18; and
  • To determine whether HIV infection status affects the protective effectiveness of HPV vaccines.

Investigators

  • Prof Sinead Delany-Moretlwe, Principal Investigator

Latest Update:

March 2024

For more about HOPE (HPV One and two dose Population Effectiveness) Study please email rhicomms@wrhi.ac.za

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