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Wits RHI

HOPE Study

Sexual and Reproductive Health

The HOPE (HPV One and Two Dose Population Effectiveness) Study is investigating the impact of 1-dose and 2-dose human papillomavirus (HPV) vaccination schedules on the prevalence of HPV in South African adolescent girls. This research aims to evaluate the effectiveness of these vaccination schedules in reducing community-level HPV prevalence within this population.

Purpose

The purpose of the study is to monitor the effectiveness of 1-dose and 2-dose HPV vaccination schedules on community-level HPV prevalence among South African adolescent girls.

Primary Objectives

In South African adolescent girls aged 17–18 years, the study aims to:

  • Measure the population effectiveness of the national 2-dose HPV vaccine schedule, administered at age 9, in protecting against infections with sexually transmitted HPV types 16 and 18.
  • Assess the population effectiveness of a 1-dose HPV vaccine schedule delivered via a demonstration project to girls in Grade 10 at public schools, in protecting against infections with sexually transmitted HPV types 16 and 18.

Secondary Objectives

  • Determine whether HIV infection status affects the protective effectiveness of HPV vaccines.
  • Measure the extent of vaccine cross-protection and herd protection following the national 2-dose vaccine schedule administered at age 9.
  • Identify sociodemographic and behavioral correlates of uptake and the impact of the national 2-dose program.

Investigators

  • Prof Sinead Delany-Moretlwe, Principal Investigator

Media Coverage

  1. Spotlight, 19 June 2024: HPV vaccination switching to single dose and private schools to get government supply
  2. Juta  Medical Brief, 13 February 2019: Wits RHI launch Africa’s first HPV vaccine impact evaluation project

Latest Update

June 2024

For more about HOPE Study please email rhicomms@wrhi.ac.za

Research Brief

HOPE Study