Rationale
Previous research in Cape Town, South Africa, has shown a strong interest among young people, both men and women in using long-acting injectable and implantable HIV prevention products. Findings from the iPrevent Discrete Choice Experiment (DCE) revealed that 67% of heterosexual men and men who have sex with men (MSM) preferred a 6-month implant over a bimonthly injection, compared to 52% of women.
The South African Male User Research on Acceptability of Implants and Injections (SAMURAI) study aims to explore these preferences further through placebo crossover studies. Unlike traditional clinical trials, this approach allows participants to experience the different dosing platforms directly, offering real-world insights into acceptability and feasibility. This method has been successfully used in prior studies, such as the Trio and Quatro trials, where participants’ preferences evolved after hands-on experience with novel HIV prevention methods.
By focusing on delivery mechanisms rather than drug efficacy, the study seeks to determine which long-acting prevention methods men find most acceptable, balancing factors such as duration of protection, frequency of clinic visits, and ease of use. These insights will inform the development of HIV prevention strategies that are both effective and user-friendly, ensuring better uptake and adherence among men, including heterosexual and MSM populations.
Objectives
The SAMURAI study aims to:
- Evaluate men’s preferences and trade-offs regarding long-acting HIV prevention methods.
- Assess the acceptability and feasibility of implants versus injections.
- Provide critical data to guide product development and implementation strategies.
Study Approach
This study involves minimal to moderate risks, as it does not use pharmaceutical drugs. Implant insertions are considered moderate clinical procedures, while injections are minor. The findings will contribute significantly to understanding men’s willingness and ability to use long-acting HIV prevention methods.
Investigators
Wits RHI:
- Prof Thesla Palanee-Phillips (Co-Principal Investigator)
- Dr Nkosiphile Ndlovu (Co-Principal Investigator)
Other Partners & Collaborators:
- Desmond Tutu Health Research Foundation
- Dr Katherine Margaret Kill (Principal Investigator)
- Women’s Global Health Imperative at RTI International
- Elizabeth Montgomery (Principal Investigator)
- Alexandra Minnis (Co-Principal Investigator)
Latest Update
April 2024
For more details about SAMURAI study, please email rhicomms@wrhi.ac.za
